Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

Neuroinflammatory processes are recognized key contributory factors in Parkinson's disease (PD) physiopathology. While the causes responsible for the progressive loss of midbrain dopaminergic (mDA) neuronal cell bodies in the subtantia nigra pars compacta are poorly understood, aging, genetics,...

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Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: L'Episcopo, Francesca, Tirolo, Cataldo, Serapide, Maria F., Caniglia, Salvatore, Testa, Nunzio, Leggio, Loredana, Vivarelli, Silvia, Iraci, Nunzio, Pluchino, Stefano, Marchetti, Bianca
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816064/
https://ncbi.nlm.nih.gov/pubmed/29483868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00012
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