Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling

Wnts modulate cell proliferation, differentiation and stem cell self-renewal, by inducing β-catenin dependent signaling through Frizzled (Fzd) and Lrp5/6 to regulate cell fate decisions, and the growth and repair of a multitude of tissues(1). The 19 mammalian Wnts interact promiscuously with the 10...

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Publié dans:Nature
Auteurs principaux: Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815871/
https://ncbi.nlm.nih.gov/pubmed/28467818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22306
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