Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling

Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interactions with Leucine-rich repeat-containing G-protein...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Luca, Vincent C., Miao, Yi, Li, Xingnan, Hollander, Michael J., Kuo, Calvin J., Garcia, K. Christopher
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949110/
https://ncbi.nlm.nih.gov/pubmed/31914456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226928
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