Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling

Wnts modulate cell proliferation, differentiation and stem cell self-renewal, by inducing β-catenin dependent signaling through Frizzled (Fzd) and Lrp5/6 to regulate cell fate decisions, and the growth and repair of a multitude of tissues(1). The 19 mammalian Wnts interact promiscuously with the 10...

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書誌詳細
出版年:Nature
主要な著者: Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815871/
https://ncbi.nlm.nih.gov/pubmed/28467818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22306
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