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Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling

Wnts modulate cell proliferation, differentiation and stem cell self-renewal, by inducing β-catenin dependent signaling through Frizzled (Fzd) and Lrp5/6 to regulate cell fate decisions, and the growth and repair of a multitude of tissues(1). The 19 mammalian Wnts interact promiscuously with the 10...

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Podrobná bibliografie
Vydáno v:Nature
Hlavní autoři: Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815871/
https://ncbi.nlm.nih.gov/pubmed/28467818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22306
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