Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hong, Xuehui, Huang, He, Qiu, Xingfeng, Ding, Zhijie, Feng, Xing, Zhu, Yuekun, Zhuo, Huiqin, Hou, Jingjing, Zhao, Jiabao, Cai, Wangyu, Sha, Ruihua, Hong, Xinya, Li, Yongxiang, Song, Hongjiang, Zhang, Zhiyong
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815853/
https://ncbi.nlm.nih.gov/pubmed/29384474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29511
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados