Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that...

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Pubblicato in:eLife
Autori principali: Hong, Xuehui, Huang, He, Qiu, Xingfeng, Ding, Zhijie, Feng, Xing, Zhu, Yuekun, Zhuo, Huiqin, Hou, Jingjing, Zhao, Jiabao, Cai, Wangyu, Sha, Ruihua, Hong, Xinya, Li, Yongxiang, Song, Hongjiang, Zhang, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815853/
https://ncbi.nlm.nih.gov/pubmed/29384474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29511
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