Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:eLife
Main Authors: Hong, Xuehui, Huang, He, Qiu, Xingfeng, Ding, Zhijie, Feng, Xing, Zhu, Yuekun, Zhuo, Huiqin, Hou, Jingjing, Zhao, Jiabao, Cai, Wangyu, Sha, Ruihua, Hong, Xinya, Li, Yongxiang, Song, Hongjiang, Zhang, Zhiyong
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2018
נושאים:
Cancer Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815853/
https://ncbi.nlm.nih.gov/pubmed/29384474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29511
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