Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes

Global neurodevelopmental delay is a prominent characteristic of individuals with Prader-Willi syndrome (PWS). The neuromolecular bases for these delays are unknown. We identified neuroanatomical changes in the brains of mice deficient for a gene in the minimal critical deletion region for PWS (Snor...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Burnett, Lisa Cole, Hubner, Gabriela, LeDuc, Charles A, Morabito, Michael V, Carli, Jayne F Martin, Leibel, Rudolph L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815655/
https://ncbi.nlm.nih.gov/pubmed/28973544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx342
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