TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children

PURPOSE: Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fr...

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Pubblicato in:J Clin Oncol
Autori principali: Qian, Maoxiang, Cao, Xueyuan, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Dai, Yunfeng, Carroll, Andrew, Heerema, Nyla A., Zhang, Hui, Moriyama, Takaya, Gastier-Foster, Julie M., Xu, Heng, Raetz, Elizabeth, Larsen, Eric, Winick, Naomi, Bowman, W. Paul, Martin, Paul L., Mardis, Elaine R., Fulton, Robert, Zambetti, Gerard, Borowitz, Michael, Wood, Brent, Nichols, Kim E., Carroll, William L., Pui, Ching-Hon, Mullighan, Charles G., Evans, William E., Hunger, Stephen P., Relling, Mary V., Loh, Mignon L., Yang, Jun J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2018
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815403/
https://ncbi.nlm.nih.gov/pubmed/29300620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2017.75.5215
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