TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children

PURPOSE: Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fr...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Qian, Maoxiang, Cao, Xueyuan, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Dai, Yunfeng, Carroll, Andrew, Heerema, Nyla A., Zhang, Hui, Moriyama, Takaya, Gastier-Foster, Julie M., Xu, Heng, Raetz, Elizabeth, Larsen, Eric, Winick, Naomi, Bowman, W. Paul, Martin, Paul L., Mardis, Elaine R., Fulton, Robert, Zambetti, Gerard, Borowitz, Michael, Wood, Brent, Nichols, Kim E., Carroll, William L., Pui, Ching-Hon, Mullighan, Charles G., Evans, William E., Hunger, Stephen P., Relling, Mary V., Loh, Mignon L., Yang, Jun J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2018
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815403/
https://ncbi.nlm.nih.gov/pubmed/29300620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2017.75.5215
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