TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children

PURPOSE: Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fr...

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Publicat a:J Clin Oncol
Autors principals: Qian, Maoxiang, Cao, Xueyuan, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Dai, Yunfeng, Carroll, Andrew, Heerema, Nyla A., Zhang, Hui, Moriyama, Takaya, Gastier-Foster, Julie M., Xu, Heng, Raetz, Elizabeth, Larsen, Eric, Winick, Naomi, Bowman, W. Paul, Martin, Paul L., Mardis, Elaine R., Fulton, Robert, Zambetti, Gerard, Borowitz, Michael, Wood, Brent, Nichols, Kim E., Carroll, William L., Pui, Ching-Hon, Mullighan, Charles G., Evans, William E., Hunger, Stephen P., Relling, Mary V., Loh, Mignon L., Yang, Jun J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2018
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ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815403/
https://ncbi.nlm.nih.gov/pubmed/29300620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2017.75.5215
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