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The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action

Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function. A surface on the OB domain of TPP1 called the TEL patch is critical for TPP1’s telomerase-associated functions. Here, we identify a separate regi...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Grill, Sherilyn, Tesmer, Valerie M., Nandakumar, Jayakrishnan
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815312/
https://ncbi.nlm.nih.gov/pubmed/29386102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.012
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