FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer cell...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Pentzold, Constanze, Shah, Shiraz Ali, Hansen, Niels Richard, Le Tallec, Benoît, Seguin-Orlando, Andaine, Debatisse, Michelle, Lisby, Michael, Oestergaard, Vibe H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815096/
https://ncbi.nlm.nih.gov/pubmed/29253234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1260
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