FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer cell...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Pentzold, Constanze, Shah, Shiraz Ali, Hansen, Niels Richard, Le Tallec, Benoît, Seguin-Orlando, Andaine, Debatisse, Michelle, Lisby, Michael, Oestergaard, Vibe H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815096/
https://ncbi.nlm.nih.gov/pubmed/29253234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1260
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