Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer’s Disease

BACKGROUND: ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. Tramiprosate, the active agent, is a small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor that was evaluated extensively in preclinical and clinical investigations for the treatment of Alzheimer’s...

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Bibliografiska uppgifter
I publikationen:Clin Pharmacokinet
Huvudupphovsmän: Hey, John A., Yu, Jeremy Y., Versavel, Mark, Abushakra, Susan, Kocis, Petr, Power, Aidan, Kaplan, Paul L., Amedio, John, Tolar, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2017
Ämnen:
Original Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814546/
https://ncbi.nlm.nih.gov/pubmed/29063518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0608-3
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