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Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain

BACKGROUND: ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation in clinical development for Alzheimer’s disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability. During clinical studies, we discover...

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Bibliografiske detaljer
Udgivet i:CNS Drugs
Main Authors: Hey, John A., Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y., Tolar, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153967/
https://ncbi.nlm.nih.gov/pubmed/30076539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40263-018-0554-0
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