Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

A large body of clinical and nonclinical evidence supports the role of neurotoxic soluble beta amyloid (amyloid, Aβ) oligomers as upstream pathogenic drivers of Alzheimer’s disease (AD). Recent late-stage trials in AD that have evaluated agents targeting distinct species of Aβ provide compelling evi...

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Sparad:
Bibliografiska uppgifter
I publikationen:Int J Mol Sci
Huvudupphovsmän: Tolar, Martin, Hey, John, Power, Aidan, Abushakra, Susan
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2021
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231952/
https://ncbi.nlm.nih.gov/pubmed/34198582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126355
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