Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction

YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase LATS. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of LATS. Their isoforms, YAP2 and LATS1 contain two WW dom...

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Vydáno v:Oncotarget
Hlavní autoři: Verma, Apoorva, Jing-Song, Fan, Finch-Edmondson, Megan L., Velazquez-Campoy, Adrian, Balasegaran, Shanker, Sudol, Marius, Sivaraman, Jayaraman
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814282/
https://ncbi.nlm.nih.gov/pubmed/29487715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23909
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