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WW Domains of the Yes-Kinase-Associated-Protein (YAP) Transcriptional Regulator Behave as Independent Units with Different Binding Preferences for PPxY Motif-Containing Ligands

YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor. Elucidating the degree of co-operation between these WW domain...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Iglesias-Bexiga, Manuel, Castillo, Francisco, Cobos, Eva S., Oka, Tsutomu, Sudol, Marius, Luque, Irene
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301871/
https://ncbi.nlm.nih.gov/pubmed/25607641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113828
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