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Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4

The recognition of PPxY viral Late domains by the third WW domain of the HECT-E3 ubiquitin ligase NEDD4 (hNEDD4-WW3) is essential for the completion of the budding process of numerous enveloped viruses, including Ebola, Marburg, HTLV1 or Rabies. hNEDD4-WW3 has been validated as a promising target fo...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Iglesias-Bexiga, Manuel, Palencia, Andrés, Corbi-Verge, Carles, Martin-Malpartida, Pau, Blanco, Francisco J., Macias, Maria J., Cobos, Eva S., Luque, Irene
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803667/
https://ncbi.nlm.nih.gov/pubmed/31636332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50701-3
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