Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction

YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase LATS. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of LATS. Their isoforms, YAP2 and LATS1 contain two WW dom...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Verma, Apoorva, Jing-Song, Fan, Finch-Edmondson, Megan L., Velazquez-Campoy, Adrian, Balasegaran, Shanker, Sudol, Marius, Sivaraman, Jayaraman
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2018
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814282/
https://ncbi.nlm.nih.gov/pubmed/29487715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23909
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы