Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propo...

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Udgivet i:PLoS One
Main Authors: Sumi, Chisato, Okamoto, Akihisa, Tanaka, Hiromasa, Nishi, Kenichiro, Kusunoki, Munenori, Shoji, Tomohiro, Uba, Takeo, Matsuo, Yoshiyuki, Adachi, Takehiko, Hayashi, Jun-Ichi, Takenaga, Keizo, Hirota, Kiichi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813975/
https://ncbi.nlm.nih.gov/pubmed/29447230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192796
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