Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propo...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Sumi, Chisato, Okamoto, Akihisa, Tanaka, Hiromasa, Nishi, Kenichiro, Kusunoki, Munenori, Shoji, Tomohiro, Uba, Takeo, Matsuo, Yoshiyuki, Adachi, Takehiko, Hayashi, Jun-Ichi, Takenaga, Keizo, Hirota, Kiichi
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813975/
https://ncbi.nlm.nih.gov/pubmed/29447230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192796
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