The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

BACKGROUND: The local anesthetic lidocaine can affect intra- and extra-cellular signaling pathways in both neuronal and non-neuronal cells, resulting in long-term modulation of biological functions, including cell growth and death. Indeed, lidocaine was shown to induce necrosis and apoptosis in vitr...

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Pubblicato in:BMC Anesthesiol
Autori principali: Okamoto, Akihisa, Tanaka, Masahiro, Sumi, Chisato, Oku, Kanako, Kusunoki, Munenori, Nishi, Kenichiro, Matsuo, Yoshiyuki, Takenaga, Keizo, Shingu, Koh, Hirota, Kiichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078905/
https://ncbi.nlm.nih.gov/pubmed/27776485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-016-0273-3
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