HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function. Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the involveme...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Okamoto, Akihisa, Sumi, Chisato, Tanaka, Hiromasa, Kusunoki, Munenori, Iwai, Teppei, Nishi, Kenichiro, Matsuo, Yoshiyuki, Harada, Hiroshi, Takenaga, Keizo, Bono, Hidemasa, Hirota, Kiichi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476559/
https://ncbi.nlm.nih.gov/pubmed/28630416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03980-7
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