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HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death
The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function. Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the involveme...
में बचाया:
| में प्रकाशित: | Sci Rep |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5476559/ https://ncbi.nlm.nih.gov/pubmed/28630416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03980-7 |
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