Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance

Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting smoothened (SMO), an essential effector of canonical HH/GLI signaling, show significant clinical success...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Cancer
Auteurs principaux: Gruber, Wolfgang, Peer, Elisabeth, Elmer, Dominik P., Sternberg, Christina, Tesanovic, Suzana, del Burgo, Pedro, Coni, Sonia, Canettieri, Gianluca, Neureiter, Daniel, Bartz, René, Kohlhof, Hella, Vitt, Daniel, Aberger, Fritz
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Molecular Cancer Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813224/
https://ncbi.nlm.nih.gov/pubmed/29055107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31117
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