DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

A wide range of human malignancies displays aberrant activation of Hedgehog (HH)/GLI signaling, including cancers of the skin, brain, gastrointestinal tract and hematopoietic system. Targeting oncogenic HH/GLI signaling with small molecule inhibitors of the essential pathway effector Smoothened (SMO...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gruber, Wolfgang, Hutzinger, Martin, Elmer, Dominik Patrick, Parigger, Thomas, Sternberg, Christina, Cegielkowski, Lukasz, Zaja, Mirko, Leban, Johann, Michel, Susanne, Hamm, Svetlana, Vitt, Daniel, Aberger, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872774/
https://ncbi.nlm.nih.gov/pubmed/26784250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6910
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