Cross-priming induces immunodomination in the presence of viral MHC class I inhibition

Viruses have evolved mechanisms of MHCI inhibition in order to evade recognition by cytotoxic CD8(+) T cells (CTLs), which is well-illustrated by our prior studies on cowpox virus (CPXV) that encodes potent MHCI inhibitors. Deletion of CPXV viral MHCI inhibitors markedly attenuated in vivo infection...

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Udgivet i:PLoS Pathog
Main Authors: Lauron, Elvin J., Yang, Liping, Elliott, Jabari I., Gainey, Maria D., Fremont, Daved H., Yokoyama, Wayne M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812664/
https://ncbi.nlm.nih.gov/pubmed/29444189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006883
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