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Viral MHC class I inhibition evades CD8(+) T-cell effector responses in vivo but not CD8(+) T-cell priming

Although viral MHC class I inhibition is considered a classic immune-evasion strategy, its in vivo role is largely unclear. Mutant cowpox virus lacking its MHC class I inhibitors is markedly attenuated during acute infection because of CD8(+) T-cell–dependent control, but it was not known how CD8(+)...

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Detalhes bibliográficos
Main Authors: Gainey, Maria D., Rivenbark, Joshua G., Cho, Hyelim, Yang, Liping, Yokoyama, Wayne M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511129/
https://ncbi.nlm.nih.gov/pubmed/23112205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217111109
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