MHC Class I Cross-Presentation by Dendritic Cells Counteracts Viral Immune Evasion

DCs very potently activate CD8(+) T cells specific for viral peptides bound to MHC class I molecules. However, many viruses have evolved immune evasion mechanisms, which inactivate infected DCs and might reduce priming of T cells. Then MHC class I cross-presentation of exogenous viral Ag by non-infe...

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Bibliografiska uppgifter
Huvudupphovsmän: Nopora, Katrin, Bernhard, Caroline A., Ried, Christine, Castello, Alejandro A., Murphy, Kenneth M., Marconi, Peggy, Koszinowski, Ulrich, Brocker, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2012
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505839/
https://ncbi.nlm.nih.gov/pubmed/23189079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00348
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