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Post transcriptional regulation of HLA-A protein expression by alternative polyadenylation signals involving the RNA binding protein Syncrip

Genomic variation in the untranslated region (UTR) has been shown to influence human leukocyte antigen (HLA) class I expression level, and associate with disease outcomes. Sequencing of the 3’UTR of common HLA-A alleles indicated the presence of two polyadenylation signals (PAS). The proximal PAS is...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Kulkarni, Smita, Ramsuran, Veron, Rucevic, Marijana, Singh, Sukhvinder, Lied, Alexandra, Kulkarni, Viraj, O’hUigin, Colm, Le Gall, Sylvie, Carrington, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812486/
https://ncbi.nlm.nih.gov/pubmed/29055006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700697
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