Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

Variation in the 3′ untranslated region (3′UTR) of the HLA-C locus determines binding of the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind miR-148a relative to those alleles that escape its binding. The HLA-C 3′UTR variant was shown to associate with HIV cont...

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Autores principales: Kulkarni, Smita, Qi, Ying, O’hUigin, Colm, Pereyra, Florencia, Ramsuran, Veron, McLaren, Paul, Fellay, Jacques, Nelson, George, Chen, Haoyan, Liao, Wilson, Bass, Sara, Apps, Richard, Gao, Xiaojiang, Yuki, Yuko, Lied, Alexandra, Ganesan, Anuradha, Hunt, Peter W., Deeks, Steven G., Wolinsky, Steven, Walker, Bruce D., Carrington, Mary
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870724/
https://ncbi.nlm.nih.gov/pubmed/24248364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312237110
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