Mitotic inheritance of mRNA facilitates translational activation of the osteogenic-lineage commitment factor Runx2 in progeny of osteoblastic cells

Epigenetic mechanisms mediate the acquisition of specialized cellular phenotypes during tissue development, maintenance and repair. When phenotype-committed cells transit through mitosis, chromosomal condensation counteracts epigenetic activation of gene expression. Subsequent post-mitotic re-activa...

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Udgivet i:J Cell Physiol
Main Authors: Varela, Nelson, Aranguiz, Alejandra, Lizama, Carlos, Sepulveda, Hugo, Antonelli, Marcelo, Thaler, Roman, Moreno, Ricardo D., Montecino, Martin, Stein, Gary S., van Wijnen, Andre J., Galindo, Mario
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812339/
https://ncbi.nlm.nih.gov/pubmed/26381402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25188
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