Identification of an (−)‐englerin A analogue, which antagonizes (−)‐englerin A at TRPC1/4/5 channels

BACKGROUND AND PURPOSE: (−)‐Englerin A (EA) is a potent cytotoxic agent against renal carcinoma cells. It achieves its effects by activation of transient receptor potential canonical (TRPC)4/TRPC1 heteromeric channels. It is also an agonist at channels formed by the related protein, TRPC5. Here, we...

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Publicat a:Br J Pharmacol
Autors principals: Rubaiy, Hussein N, Seitz, Tobias, Hahn, Sven, Choidas, Axel, Habenberger, Peter, Klebl, Bert, Dinkel, Klaus, Nussbaumer, Peter, Waldmann, Herbert, Christmann, Mathias, Beech, David J
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811624/
https://ncbi.nlm.nih.gov/pubmed/29247460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14128
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