Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

BACKGROUND: Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a primate renal allograft model, but rodent transpla...

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Publicado en:Transplant Direct
Main Authors: O’Neill, Natalie A., Zhang, Tianshu, Braileanu, Gheorghe, Cheng, Xiangfei, Hershfeld, Alena, Sun, Wenji, Reimann, Keith A., Dahi, Sia, Kubicki, Natalia, Hassanein, Wessam, Laird, Christopher, Cimeno, Arielle, Azimzadeh, Agnes M., Pierson, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2018
Assuntos:
Basic Science
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811273/
https://ncbi.nlm.nih.gov/pubmed/29464205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000000761
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