Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in CD154-treated monkeys

BACKGROUND: Anti-CD154 monotherapy is associated with anti-donor alloantibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibition (CNI), these pathogenic phenomena are delayed...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Azimzadeh, Agnes M., Zhang, Tianshu, Wu, Guosheng, Kelishadi, Shahrooz S., Stoddard, Tiffany, O’Neill, Natalie, Nguyen, Bao-Ngoc, Welty, Emily, Avon, Christopher, Higuchi, Mitch, Mitchell, Stuart L., Hershfeld, Alena, Cheng, XiangFei, Kronfli, Anthony, Rybak, Elana, Burdorf, Lars, Pierson, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179283/
https://ncbi.nlm.nih.gov/pubmed/27362307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001258
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