Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in CD154-treated monkeys

BACKGROUND: Anti-CD154 monotherapy is associated with anti-donor alloantibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibition (CNI), these pathogenic phenomena are delayed...

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Gepubliceerd in:Transplantation
Hoofdauteurs: Azimzadeh, Agnes M., Zhang, Tianshu, Wu, Guosheng, Kelishadi, Shahrooz S., Stoddard, Tiffany, O’Neill, Natalie, Nguyen, Bao-Ngoc, Welty, Emily, Avon, Christopher, Higuchi, Mitch, Mitchell, Stuart L., Hershfeld, Alena, Cheng, XiangFei, Kronfli, Anthony, Rybak, Elana, Burdorf, Lars, Pierson, Richard N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179283/
https://ncbi.nlm.nih.gov/pubmed/27362307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001258
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