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Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition
Due to the formation of hydrolysis-susceptible adducts, the 1,3-dipolar cycloaddition between an azide and strained trans-cyclooctene (TCO) has been disregarded in the field of bioorthogonal chemistry. We report a method which uses the instability of the adducts to our advantage in a prodrug activat...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811098/ https://ncbi.nlm.nih.gov/pubmed/29560207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02574a |
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