Cargando...
Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition
Due to the formation of hydrolysis-susceptible adducts, the 1,3-dipolar cycloaddition between an azide and strained trans-cyclooctene (TCO) has been disregarded in the field of bioorthogonal chemistry. We report a method which uses the instability of the adducts to our advantage in a prodrug activat...
Guardado en:
| Publicado en: | Chem Sci |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Royal Society of Chemistry
2015
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811098/ https://ncbi.nlm.nih.gov/pubmed/29560207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02574a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|