Complement activation via a C3a receptor pathway alters CD4+ T lymphocytes and mediates lung cancer progression

The complement cascade is a part of the innate immune system which acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotop...

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Publicat a:Cancer Res
Autors principals: Kwak, Jeff W., Laskowski, Jennifer, Li, Howard Y., McSharry, Maria V., Sippel, Trisha R., Bullock, Bonnie L., Johnson, Amber M., Poczobutt, Joanna M., Neuwelt, Alexander J., Malkoski, Stephen P., Weiser-Evans, Mary C., Lambris, John, Clambey, Eric T., Thurman, Joshua M., Nemenoff, Raphael A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810934/
https://ncbi.nlm.nih.gov/pubmed/29118090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0240
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