Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

AIM: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin. METHODS: We performed an open‐label, randomized, two‐phase, five‐drug clinical pharmacokinetic cocktail crossover study in 12 healthy men with and without pretreatment with 1 g dicloxacillin three tim...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Stage, Tore Bjerregaard, Graff, Magnus, Wong, Susan, Rasmussen, Louise Ladebo, Nielsen, Flemming, Pottegård, Anton, Brøsen, Kim, Kroetz, Deanna L., Khojasteh, S. Cyrus, Damkier, Per
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Drug Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809358/
https://ncbi.nlm.nih.gov/pubmed/29105855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13467
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