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Quantification of In Vivo Metabolic Activity of CYP2D6 Genotypes and Alleles Through Population Pharmacokinetic Analysis of Vortioxetine

Assignment of CYP2D6 phenotype from genotype data can be challenging and despite efforts to standardize translation, there is currently no universally accepted method. To facilitate standardization, there remains a need to precisely quantify the in vivo function of different CYP2D6 genotypes. Vortio...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Frederiksen, Trine, Areberg, Johan, Schmidt, Ellen, Bjerregaard Stage, Tore, Brøsen, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818194/
https://ncbi.nlm.nih.gov/pubmed/32599653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1972
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