Paracetamol decreases steady‐state exposure to lamotrigine by induction of glucuronidation in healthy subjects

AIM: Patients receiving lamotrigine therapy frequently use paracetamol concomitantly. While one study suggests a possible, clinically relevant drug–drug interaction, practical recommendations of the concomitant use are inconsistent. We performed a systematic pharmacokinetic study in healthy voluntee...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Clin Pharmacol
Egile Nagusiak: Gastrup, Sandra, Stage, Tore Bjerregaard, Fruekilde, Palle Bach Nielsen, Damkier, Per
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Drug Interactions
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799936/
https://ncbi.nlm.nih.gov/pubmed/26588196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12840
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