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Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

BACKGROUND: T-cell depletion (TCD) effectively reduces severe graft-versus-host disease in recipients of HLA-mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of CD45RA+ naïve T cells, rather than broad de...

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Detaylı Bibliyografya
Yayımlandı:Transpl Infect Dis
Asıl Yazarlar: Triplett, Brandon M., Muller, Brad, Kang, Guolian, Li, Ying, Cross, Shane J, Moen, Joseph, Cunningham, Lea, Janssen, William, Mamcarz, Ewelina, Shook, David R., Srinivasan, Ashok, Choi, John, Hayden, Randall T., Leung, Wing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809307/
https://ncbi.nlm.nih.gov/pubmed/29178554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tid.12823
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