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Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

BACKGROUND: T-cell depletion (TCD) effectively reduces severe graft-versus-host disease in recipients of HLA-mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of CD45RA+ naïve T cells, rather than broad de...

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Pubblicato in:Transpl Infect Dis
Autori principali: Triplett, Brandon M., Muller, Brad, Kang, Guolian, Li, Ying, Cross, Shane J, Moen, Joseph, Cunningham, Lea, Janssen, William, Mamcarz, Ewelina, Shook, David R., Srinivasan, Ashok, Choi, John, Hayden, Randall T., Leung, Wing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809307/
https://ncbi.nlm.nih.gov/pubmed/29178554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tid.12823
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