Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

BACKGROUND: T-cell depletion (TCD) effectively reduces severe graft-versus-host disease in recipients of HLA-mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of CD45RA+ naïve T cells, rather than broad de...

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Bibliographic Details
Published in:Transpl Infect Dis
Main Authors: Triplett, Brandon M., Muller, Brad, Kang, Guolian, Li, Ying, Cross, Shane J, Moen, Joseph, Cunningham, Lea, Janssen, William, Mamcarz, Ewelina, Shook, David R., Srinivasan, Ashok, Choi, John, Hayden, Randall T., Leung, Wing
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809307/
https://ncbi.nlm.nih.gov/pubmed/29178554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tid.12823
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