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Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

BACKGROUND: T-cell depletion (TCD) effectively reduces severe graft-versus-host disease in recipients of HLA-mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of CD45RA+ naïve T cells, rather than broad de...

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Publicat a:Transpl Infect Dis
Autors principals: Triplett, Brandon M., Muller, Brad, Kang, Guolian, Li, Ying, Cross, Shane J, Moen, Joseph, Cunningham, Lea, Janssen, William, Mamcarz, Ewelina, Shook, David R., Srinivasan, Ashok, Choi, John, Hayden, Randall T., Leung, Wing
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809307/
https://ncbi.nlm.nih.gov/pubmed/29178554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tid.12823
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