Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase

Ribonucleotide reductase (RR), an established cancer target is usually inhibited by antimetabolites which display multiple cross-reactive effects. Recently, we discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH or E-3a) of human RR (hRR) binding at the catalytic site (C-site) and inh...

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Publicado en:J Med Chem
Main Authors: Huff, Sarah E., Mohammed, Faiz Ahmad, Yang, Mu, Agrawal, Prashansa, Pink, John, Harris, Michael E., Dealwis, Chris G., Viswanathan, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808567/
https://ncbi.nlm.nih.gov/pubmed/29253340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00530
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