(18)F-Radiolabeled Panobinostat Allows for Positron Emission Tomography Guided Delivery of a Histone Deacetylase Inhibitor

[Image: see text] Histone deacetylase (HDAC) inhibition is becoming an increasingly popular approach to treat cancer, as HDAC overexpression is common in many malignancies. The blood–brain barrier (BBB) prevents systemically delivered drugs from reaching brain at effective concentration, making smal...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kommidi, Harikrishna, Tosi, Umberto, Maachani, Uday B., Guo, Hua, Marnell, Christopher S., Law, Benedict, Souweidane, Mark M., Ting, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807872/
https://ncbi.nlm.nih.gov/pubmed/29456798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00471
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