(18)F-Radiolabeled Panobinostat Allows for Positron Emission Tomography Guided Delivery of a Histone Deacetylase Inhibitor

[Image: see text] Histone deacetylase (HDAC) inhibition is becoming an increasingly popular approach to treat cancer, as HDAC overexpression is common in many malignancies. The blood–brain barrier (BBB) prevents systemically delivered drugs from reaching brain at effective concentration, making smal...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Kommidi, Harikrishna, Tosi, Umberto, Maachani, Uday B., Guo, Hua, Marnell, Christopher S., Law, Benedict, Souweidane, Mark M., Ting, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807872/
https://ncbi.nlm.nih.gov/pubmed/29456798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00471
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