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A murine model for quantitative, real-time evaluation of convection-enhanced delivery (RT-CED) using an (18)[F]-positron emitting, fluorescent derivative of dasatinib
The blood brain barrier can limit the efficacy of systemically delivered drugs in treating neurological malignancies; therefore, alternate routes of drug administration must be considered. The Abl-kinase inhibitor, dasatinib, is modified to give compound 1 ([(18)F]-1) so that (18)F-positron emission...
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| Publié dans: | Mol Cancer Ther |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6287766/ https://ncbi.nlm.nih.gov/pubmed/28978723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0423 |
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