Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Anion selective ionophores, anionophores, are small molecules capable of facilitating the transmembrane transport of anions. Inspired in the structure of natural product prodigiosin, four novel anionophores 1a-d, including a 1,2,3-triazole group, were prepared. These compounds proved highly efficien...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hernando, Elsa, Capurro, Valeria, Cossu, Claudia, Fiore, Michele, García-Valverde, María, Soto-Cerrato, Vanessa, Pérez-Tomás, Ricardo, Moran, Oscar, Zegarra-Moran, Olga, Quesada, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805763/
https://ncbi.nlm.nih.gov/pubmed/29422673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20708-3
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